Because of the concentration of CB receptors in key regions of the brain, especially the limbic system, cerebral cortex and cerebellum, the endocannabinoid system regulates an enormous number of key cognitive, motor, and signaling processes. Additionally, the endocannabinoid system serves as a primary defense mechanism for the brain, regulating mitochondrial activity, providing antioxidant protection, and regulating neurogenesis, mood, memory, appetite, pain levels, and reward, plus the physiological response to brain injury and insult. The fundamental role of the ECS in metabolic mental illnesses such as schizophrenia, depression and anxiety make the endocannabinoid system a primary therapeutic target and focus of Phytecs research. The emerging role of phytocannabinoids and semi-synthetic derivatives in the treatment CNS conditions including seizure disorders, multiple sclerosis, Alzheimer’s, Huntington’s and neuroimmune disorders appears promising.
The brain regions illustrated include elements of limbic system: the hippocampus and the amygdala, where CB1 receptors regulate memory and emotion. Endocannabinoids help modulate movement and help us learn new movements. Appetite, pain levels, and reward are also mediated by endocannabinoids within the brain. The endocannabinoid balance of the brain is dysregulated in a wide range of neurological disorders from Alzheimer’s to Huntington’s disease. Phytecs is developing interventions that maintain or restore endocannabinoid function within the nervous system. These products will address a wide range of conditions from anxiety to age-related brain dysfunction to drug addiction.
There is much more to endocannabinoid system and brain function than the psychoactivity of cannabis or even seizure treatment with CBD. Enlightened policy as it relates to endocannabinoid medicine embraces the mounting evidence that effective cannabinoid therapies will require polypharmacy solutions where multiple natural and semi-synthetic approaches are combined into effective medicinal entourages.
Phytecs always looks at the big research and development picture, focusing on the target rather than the arrows. Our understanding of endocannabinoid function in the brain enables Phytecs to develop the most effective solution or product to address the market need. Our partners benefit from this approach, because it allows them to skirt the fads and froth.
ECS Brain by Artwork by John Karapelou, Text by Phytecs is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License